A Practical, Simple Approach to Prescribing SGLT-2 Inhibitors for Glycemic Control, Heart Failure, or Chronic Renal Disease in Patients with and without Type 2 Diabetes Mellitus
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Keywords
SGLT-2 inhibitors, heart failure, diabetes mellitus, chronic kidney disease
Abstract
Abstract
The indications for SGLT-2 inhibitors have expanded beyond glycemic control in type 2 diabetes mellitus and now include chronic kidney disease and heart failure. These broadened indications mean more health care providers will be prescribing this class of medication on top of best evidence guideline directed therapy to improve cardiac and renal outcomes. This article reviews the effectiveness of SGLT-2i and outlines key considerations when prescribing to mitigate adverse events.
Résumé
Les indications des inhibiteurs du SGLT-2 se sont étendues au-delà du contrôle de la glycémie dans le dia-bète de type 2 et incluent maintenant les maladies rénales chroniques et l’insuffisance cardiaque. Ces indications élargies signifient qu’un plus grand nombre de fournisseurs de soins de santé prescriront cette classe de médicaments en plus du traitement dirigé par les meilleures données probantes pour améliorer les résultats cardiaques et rénaux. Cet article passe en revue l’efficacité du SGLT-2i et présente les principales considérations à prendre en compte lors de la prescription pour atténuer les effets indésirables.
References
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Olivia Cook, McMaster University, Hamilton Ontario
McMaster University, Hamilton Ontario
Ally Prebtani, McMaster University, Hamilton Ontario
Professor of Medicine, Division of Endocrinology & Metabolism, Department of Medicine, McMaster University