SGLT2 Inhibitor Use in Patients with Type 2 Diabetes Mellitus and Heart Failure

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Sarah Fraser
Elizabeth Swiggum


SGLT2 inhibitor, HFrEF, HFpEF, Congestive Heart Failure, Type 2 Diabetes Mellitus


Type 2 diabetes mellitus and heart failure, both reduced and preserved ejection fraction phenotypes, are indi-vidually associated with significant morbidity and mortality and, when co-morbid, compound their risks for poor outcomes. Sodiumglucose co-transporter 2 inhibitors have demonstrated significant risk reduction in important clinical outcomes in both conditions and should be utilized as foundational therapy to simultaneously target these two diseases. This article will explore the evidence for managing heart failure and type 2 diabetes patients and identify opportunities to improve outcomes.

Le diabète de type 2 et l’insuffisance cardiaque, qu’il s’agisse d’un phénotype de fraction d’éjection réduite ou préservée, sont associés individuellement à une morbidité et à une mortalité importantes et, en présence d’affections comorbides, exacerbent les risques de mauvais résultats. Les inhibiteurs du cotransporteur sodium-glucose de type 2 montrent une diminution importante des risques relatifs aux résultats cliniques importants dans les deux affections et devraient être utilisés comme traitement de base pour cibler les deux maladies à la fois. Cet article explore les données probantes sur la prise en charge des patients atteints d’insuffisance cardiaque et de diabète de type 2 et cerne des possibilités d’amélioration des résultats.

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